Welcome to He Lab@USTC: Development Visualized

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2025

Yue Zhang; Yuchen Xia; Xinhui Wang; Yueqin Xia; Shang Wu; Jianshuang Li; Xuan Guo#; Qinghua Zhou#; Li He#. MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains, Nature Cell Biology, Dec. 2025 [pdf]

Muhammad Ahmad; Shang Wu; Shengyao Luo; Wenjia Shi; Xuan Guo; Yuansheng Cao#; Norbert Perrimon#; Li He#. Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila, Nature Communications, Jan. 2025 [pdf]

Chen Zheng; Jiadong Zheng; Xin Wang; Yue Zhang; Xianjue Ma#; Li He#. Two-pore-domain potassium channel Sandman regulates intestinal stem cell homeostasis and tumorigenesis in Drosophila melanogaster, Journal of Genetics and Genomics, May. 2025 [pdf]

Du Kong, Xiaoqin Li, Sihua Zhao, Chenliang Wang, Zixin Cai, Sha Song, Yifan Guo, Xiaoyu Kuang, Xianping Wang, Wenhan Liu, Peng Liu, Xiaowei Guo, Wenyan Xu, Yirong Wang, Bin Zhao, Bin Jin#, Li He#, Xianjue Ma#. Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila, EMBO Journal, Jun. 2025 [pdf]

Yuxuan Sun, Boxi Sun, Xiang Cui, Weihua Li, Yue Zhang, Li He, Shutong Nong, Zhengqing Zhu, Jiyang Wu, Dongxiao Li, Xingxiang Li, Shiwu Zhang, Xiangyang Li & Mujun Li. Addressable and perceptible dynamic reprogram of ferromagnetic soft machines, Nature Communications, Mar. 2025 [pdf]

2024

Meng Liu; Li He#. Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue, Cellular and Molecular Life Sciences, Dec. 2023 [pdf]

2023

He, L; Perrimon, N. Synthetic Notch receptors and their applications to study cell-cell contacts in vivo, Developmental Cell (News and Views) , Feb, 2023 [pdf]

Yuchen Xia; Yue Zhang; Yuwei Sun; Li He#. CCDC127 regulates lipid droplet homeostasis by enhancing mitochondria-ER contacts, Biochemical and Biophysical Research Communications, Nov. 2023 [pdf]

Song Song, Bomsoo Cho, Alexis T Weiner, Silas Boye Nissen, Irene Ojeda Naharros, Pablo Sanchez Bosch, Kaye Suyama, Yanhui Hu, Li He, Tanya Svinkina, Namrata D Udeshi, Steven A Carr, Norbert Perrimon & Jeffrey D Axelrod. Protein phosphatase 1 regulates core PCP signaling, EMBO reports, Dec. 2023 [pdf]

2020

Ahmad, M, He, L, Perrimon, N. Regulation of insulin and adipokinetic hormone/glucagon production in flies. Wiley Interdiscip Rev Dev Biol. 2019 [pdf]

2019

He, L*#, Binari R, Huang J, Falo-Sanjuan J, Perrimon N#. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. Elife. 2019 May 29 [pdf]

Hunter, G. L., He, L., Perrimon, N., Charras, G., Giniger, E., and Baum, B. A role for actomyosin contractility in Notch signaling. BMC Biology. November 2019.[pdf]

2018

He, L.*#, Si, G., Huang, J., Samuel, A., and Perrimon, N#. Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature, 07 Feb. 2018. [pdf]

Parasram, K, Bernardon, N, Hammoud, M, Chang, H, He, L, Perrimon, N, Karpowicz, P. Intestinal Stem Cells Exhibit Conditional Circadian Clock Function. Stem Cell Reports. 2018 Nov 13.[pdf]

He, L., Ahmad, M., Perrimon, N., Mechanosensitive channels and their functions in stem cell differentiation. Experimental Cell Research [pdf]

2017

He, L., Huang, J., and Perrimon, N. (2017) Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor. Proceedings of the National Academy of Sciences 5467-5472[pdf]

Xu, C., Luo, J., He, L., Montell, C., and Perrimon, N. (2017) Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut. eLife. [pdf]

2016

Hunter, G. L., Hadjivasiliou, Z., Bonin, H., He, L., Perrimon, N., harras, G., and Baum, B. (2016) Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development 2305-2310. [pdf]

2015

Prasad, M., Wang, X., He, L., Cai, D., and Montell, D. J. (2015) Border cell migration: a model system for live imaging and genetic analysis of collective cell movement. Drosophila Oogenesis. Methods in Molecular Biology, vol 1328.[pdf]

Chen, C.-L., Hu, Y., Udeshi, N. D., Lau, T. Y., Wirtz-Peitz, F., He, L., Ting, A. Y., Carr, S. A., and Perrimon, N. (2015) Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Proceedings of the National Academy of Sciences 112.[pdf]

Gordon, W. R., Zimmerman, B., He, L., Miles, L. J., Huang, J., Tiyanont, K., McArthur, D. G., Aster, J. C., Perrimon, N., Loparo, J. J., and Blacklow, S. C. (2015) Mechanical allostery: evidence for a force requirement in the proteolytic activation of Notch. Developmental Cell.[pdf]

2014

Koride, S., He, L., Xiong, L.-P., Lan, G., Montell, D. J., and Sun, S. X. (2014) Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber. Molecular Biology of the Cell.[pdf]

Cai, D., Chen, S.-C., Prasad, M., He, L., Wang, X., Choesmel-Cadamuro, V., Sawyer, J. K., Danuser, G., and Montell, D. J. (2014) Mechanical feedback through Ecadherin promotes direction sensing during collective cell migration. Cell [pdf]

2012

He, L. and Montell, D. (2012) A cellular sense of touch. Nature Cell Biology (News and Views) 14, 902-903.[pdf]

2011

He, L., Wang, X., and Montell, D. J. (2011) Shining light on Drosophila oogenesis: live imaging of egg development. Current Opinion in Genetics & Development 612-619. [pdf]

Sawyer, J. K., Choi, W.*, Jung, K.-C.*, He, L.*, Harris, N. J., and Peifer, M. (2011) A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Molecular Biology of the Cell 22, 2491-2508. [pdf]

Wu, Y. I., Wang, X., He, L., Montell, D., and Hahn, K. M. (2011) Spatiotemporal control of small GTPases with light using the LOV domain. Methods in Enzymology 497, 393-407. [pdf]

Prasad, M., Wang, X., He, L., and Montell, D. J. (2011) Border cell migration: a model system for live imaging and genetic analysis of collective cell movement. Cell Migration. Methods in Molecular Biology (Methods and Protocols) [pdf]

2010

He, L.*, Wang, X.*, Tang, H. L., and Montell, D. J. (2010) Tissue elongation requires oscillating contractions of a basal actomyosin network. Nature Cell Biology 12, 1133-1142 [pdf]

Wang, X.*, He, L.*, Wu, Y. I., Hahn, K. M., and Montell, D. J. (2010) Light mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nature Cell Biology 12, 591-597 [pdf]